In a cross-disciplinary effort, Notre Dame biology and mathematics professors have published a study on stathmin, a key protein in the cytoskeleton, demonstrating the success of mathematical computer modeling and lab work in photographing of stathmin.Notre Dame associate professor of biochemistry Holly Goodson recently published the study in conjunction with professor of applied mathematics Mark Alber. “Mark Alber’s lab specializes in doing biological modeling and they had already approached us about the possibility of trying to put something together with this,” Goodson said. “We’ve actually been working on this for quite a long time. The models had to start very simply and we’ve built complexity over time.”In developing the mathematical model, Goodson said the goal was to create a system that was not overly complex. “The first thing we’re looking for is just general behavior,” she said. “Then you can add extra levels of details to make it more precise. One of the main things you can get out of something like this is to figure out what really matters.”Using computational models in a systems biology approach indirectly tests and observes conceptual models of the dynamic subcellular system, Goodson said. Although electron microscopes can capture images nanometers in size, such pictures are often incomplete, she said.“It’s like trying to understand a football game: if you’re trying to figure out football from a hundred random snapshots of the game, you would never see anything interesting,” Goodson said. “You would never see a touchdown, it would never happen. That’s kind of like electron microscopy: it’s hard to figure out what’s really going from these snapshots frozen in time.”Stathmin plays a crucial role in the destruction and uptake of microtubules, Goodson said, a dynamic, continuous process that is difficult to track. Her lab formulated conceptual ideas for the mechanism of this process, Goodman said, and obtained only limited evidence by traditional biochemical means.“It was frustrating because we couldn’t really figure out how to test if these ideas were correct,” Goodson said. “It goes back to the saying that you don’t really understand something until you can predict it quantitatively. “It’s too complicated a system to write down mathematical models — all we really know is how the individual pieces interact, but we don’t really know how that would give rise to specific predictions about the behavior of the system other than that ‘it grows’ or ‘it falls apart.’”Goodson said she studied computational biology as a rotation student working on modeling protein folding in the lab of Michael Levitt, one of the winners of the 2013 Nobel Prize in Chemistry.Goodson said she believes computational and interdisciplinary approaches are the way of the future in biology, as shown by joint efforts of Notre Dame’s biochemistry and mathematics departments.“This is an example of why it’s important for people in a variety of sciences to be learning something about biology because there’s a lot of science that’s going to be done in the next 20 years or so at this interface between biology and the other sciences,” she said.Tags: Biological Modeling
Wellington Police notes for Thursday, June 18, 2015â€¢6:37 a.m. Officers conducted a Courtesy Motor Vehicle Accident report in the 400 block E. Harvey, Wellington involving a vehicle operated by Bryan C. Tracy, 41, Wellington and a fixed object/utility pole owned by the city of Wellington.â€¢10:15 a.m. Officers took a report of an animal welfare check in the 1100 block N. Plum, Wellington by known owners.â€¢5:56 p.m. Officers took a report of found bicycle in the 1900 block E. Lincoln, Wellington.â€¢7:59 p.m. Officers took a report of suspicious activity in the 2000 block E. 16th, Wellington.â€¢10 p.m. Jackie D. Mashburn, 34, Wellington was issued a notice to appear for defective headlight and driving in violation of restrictions.
Jason tests the new strip of pathwayTHIS is the new eco-friendly path being tested on Errigal which could bring more tourists to Donegal’s famous mountain.The ‘test’ path is just six metres long and two metres wide.Everest hero Jason Black says the path through to wetter parts at the start of the Errigal walk will be welcomed by many. “It’s a test foundation to the proposed path to help with the real wet issue of getting from the carpark to the base of the mountain as most tourists and locals alike climb it in standard runners,” said Jason.“This in time should help encourage more to enjoy this iconic mountain. I do appreciate a lot have mixed views on this but really it’s no pleasure in its current state and discourages tourists and locals – young and old.“The objective is the matting allows the ground to survive in its natural state allowing water saturation and turf growth and the mess in time acts as a bind giving a firmer underfoot path like structure.”Jason added: “Time will tell.” NEW MUD-FREE PATHWAY TO ERRIGAL COULD BRING MORE TOURISTS TO DONEGAL was last modified: November 25th, 2014 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:ErrigalEverestJason Blacktest path